By Jennifer Williamson

The last decade has seen a marked shift in the treatment of prostate cancer. Fewer people are undergoing routine screening and more are choosing active surveillance over surgery or radiation. When radical prostatectomies are performed, the vast majority are robotic assisted. And now there is a growing category of focal therapies emerging as alternatives to whole-gland therapy.

One of those focal therapies, irreversible electroporation (IRE), is performed at Cleveland Clinic Indian River Hospital by board-certified urologic surgeon Jamil Syed, MD. IRE is a technique that uses pulses of electric current to target cancerous tissue in the prostate while preserving the rest of the gland.

Fewer than 200 surgeons across the country perform IRE using the NanoKnife® System, and Dr. Syed is the only Cleveland Clinic surgeon in Florida currently offering this treatment option. He trained in the procedure during his urology residency at Yale New Haven Hospital prior to joining Cleveland Clinic in 2022.

“Focal therapy is a good option for a highly select group of patients with localized low- and intermediate-risk prostate cancer,” says Dr. Syed. “These are often individuals who are not comfortable with monitoring alone, but do not want to face the potential side effects of more aggressive treatments.”

Irreversible electroporation

IRE is a surgical approach that involves placing 2 to 6 probes within a target area of tissue. Dr. Syed then delivers a series of high-voltage direct current pulses between the electrodes. This damages the membranes of the cancer cells leading to permanent cell death.

“IRE allows me to ablate the cancer while preserving nearby connective tissue and minimizing nerve damage,” explains Dr. Syed. “This form of focal therapy lessens the risk of complications, such as urinary incontinence and erectile dysfunction, seen with traditional treatments and also allows for a quicker recovery.”

He describes patients experiencing just a couple nights of soreness after the outpatient procedure, which is performed under general anesthesia.

Patient selection

According to Dr. Syed, the use of IRE in the management of localized prostate cancer should be based on risk factors and patient characteristics. Candidates should have unilateral cancer or cancer in just one quadrant of the prostate with biopsy-confirmed lesions visible on MRI scans.

“I offer this approach for certain patients with localized intermediate-risk prostate cancer, and only in very rare cases would I offer it to a patient with low-risk disease,” says Dr. Syed.

He points to improved diagnostic tools and risk stratification methods, such as advanced genomic testing and better biopsy techniques, that allow identification of patients who may benefit most from focal therapy versus standard treatments.

Shared decision-making

“Some of the most in-depth conversations I have are with individuals with intermediate-risk disease because their road forward is less clear,” says Dr. Syed. “I appreciate being able to offer some of them a middle ground with focal therapy.”

During these discussions, Dr. Syed makes it clear that IRE is considered investigational and not yet part of standard therapy. The NanoKnife System is FDA-approved for the surgical ablation of soft tissue, but has not yet received clearance for the treatment of any specific disease or condition.

“Focal therapies, like IRE, are considered less effective than whole-gland therapies, so it’s important for patients to weigh the potential benefits and risks,” says Dr. Syed.

He also emphasizes to patients that they must be closely monitored after focal therapy to evaluate the oncological effectiveness of treatment, look for signs of cancer recurrence, and to identify any new cancer that may develop in untreated areas of the prostate.

“If the cancer does return, patients are still eligible for salvage therapy with radical prostatectomy or radiotherapy,” adds Dr. Syed.

He also points out that about a third of patients who choose active surveillance will have definitive treatment within 10 years. “So many of these conversations happen across multiple visits over multiple years,” he says.