Yolanda Ortiz
December 18, 2025 – The pain in Yolanda Ortiz’s chest was relentless, but what was diagnosed after a PET scan at Memorial Hospital West may have been worse: stage four cancer that had spread from the lungs to her liver and bones.
In the nearly three years since the devastating news, Ortiz has bravely battled for her life but, until recently, had little to show for the effort. Her specific disease, extensive-stage small cell lung cancer, was progressing and mostly resistant to traditional chemotherapy. Other treatment options were limited, and hope was in short supply.
Dr. Gelenis Domingo
It’s been said it’s always darkest before the dawn, and that appropriately describes where Ortiz was before Memorial Cancer Institute doctors informed her that an immunotherapy drug called Tarlatamab had received FDA approval. A bispecific T-cell engager (BiTE), the treatment works by infusing an antibody that binds a specific protein on cancer cells and the body’s own immune system (its T-cells). By bringing cancer and T cells close together, they help the T-cells recognize and destroy the cancer.
“This is the first immunotherapy of its type approved for small cell lung cancer, an aggressive, fast-growing cancer that’s usually caused by smoking,” said Gelenis Domingo, MD. “It helps keep the disease at bay and, in the best-case scenario, the cancer becomes inactive.”
Dr. Brian Pico
While there are side effects that can be connected to the treatment – notably fatigue, muscle pain, confusion, and, in some cases, a potentially serious immune system response called cytokine release syndrome – Dr. Domingo says Memorial is one of the few facilities to have the resources to manage any issues. While the infusion takes approximately an hour and is given in ongoing cycles, patients are required to remain at the cancer institute several hours after the process to ensure there isn’t a negative reaction.
“We have one of the largest patient volumes in the state of Florida for Tarlatamab,” said Brian Pico, MD, medical director of the Solid Tumor Cellular Therapy program at Memorial Cancer Institute. “That’s a reflection of the extensive expertise we have utilizing immunotherapy and cellular therapy as treatment options.”
Ortiz, a Davie-based grandmother, gets PET scans every three months and says the images show her cancer is stable. She’s had few symptoms since beginning this treatment, with fatigue being one of them, but says she’s learned to listen to her body. “When I’m tired, I rest, for however long I need to.”
Meanwhile, the immunotherapy has already enabled Ortiz to continue to drive and spend time with family in Connecticut, a nice bonus while she waits to see if her disease may go into remission.
Memorial Cancer Institute is one of the largest cancer centers in Florida, treating nearly 5,000 newly diagnosed patients each year and pioneering advances in patient care. Through a research alliance with Florida Atlantic University, Memorial Cancer Institute is among a select group of Florida-designated “Cancer Centers of Excellence,” offering diagnosis, integrated treatment, clinical trials/research, counseling, and support services customized for the patient and their family in a healing environment close to home.
Part of Memorial Healthcare System, Memorial Cancer Institute expanded in 2024 with a 125,000 square foot center on the campus of Memorial Hospital West in Pembroke Pines that includes disease-specialized oncologists, chemotherapy infusions, a full array of radiation oncology treatments, a dedicated breast center, the Moffitt Malignant Hematology and Cellular Therapy program, the Benign Hematology program, Integrative Medicine and social work, nutrition, and navigation support services. It also features a Center for Body, Mind and Spirit for prosthetics and salon services, conference center, private infusion bays, a rooftop garden, meditation sanctuary, and an on-site café, cementing Memorial’s place as a home for world-class cancer treatment and high-quality patient and family-centered care.
To learn more, visit www.mhs.net/services/cancer.
