New program funded by National Cancer Institute grant aims to advance treatments that target the mechanisms tumors use to grow and survive
OCTOBER 28, 2022 – Cleveland Clinic’s Lerner Research Institute was awarded a five-year $12 million grant by the National Cancer Institute, part of the National Institutes of Health, to define how cytokines – proteins produced during immune response – regulate inflammation and interact with cells and molecules surrounding tumors.
Delivering cytokines in immunotherapy can signal an immune response that kills off cancer cells, but resulting inflammation also can create an environment that encourages cells to mutate and tumors to grow. Gathering detailed information on how cytokines function within specific types of cancer can help navigate the complex pathways tumors use to evade treatment and make strategies like immunotherapy more successful.
“Despite becoming more popular and holding significant potential, immunotherapies only work in a small portion of patients,” says Thomas Hamilton, Ph.D., director of Strategic Growth for Cleveland Clinic’s Chief Research and Academic Office and primary investigator of the study. “We don’t fully understand why they work in only 20-30% of patients with a particular type of cancer, and the other 70% don’t respond. I think those differences are reflected in the complexity of this research.”
The NIH funding supports the next step in a decades-long research program at the Lerner Research Institute conducting groundbreaking research on cytokines, immune response and inflammation.
Primary investigators for the research program are long-time collaborators, including Dr. Hamilton, George Stark, Ph.D., Department of Cancer Biology in Lerner Research Institute; and Mark Jackson, Ph.D., Department of Pathology at Case Western Reserve University and Associate Director for Education and Training at the Case Comprehensive Cancer Center.
Researchers are examining cytokine effects within specific cancers. Drs. Stark and Hamilton investigate lung cancer, while Dr. Jackson’s project concentrates on triple-negative breast cancer. Differentiating among different types of cancer is essential because treatments that work for one may not be effective in another, Dr. Stark says.
“Originally, cancers were categorized primarily by the organ in which they appeared,” he says. “With molecular analyses, we now realize that there are many different subtypes for each cancer. We can optimize treatment for each individual cancer because we have a much better understanding of the underlying causes.”
The program’s results have the potential to translate directly into patient care, supporting Cleveland Clinic’s approach to individualized and cutting-edge cancer treatments. “Identifying potential windows for therapy – specific cytokines, times, concentrations – all of those things might enable us to say antagonizing a specific factor or giving a specific treatment at a specific time can be beneficial,” says Dr. Hamilton.
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Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States. U.S. News & World Report consistently names Cleveland Clinic as one of the nation’s best hospitals in its annual “America’s Best Hospitals” survey. Among Cleveland Clinic’s 72,500 employees worldwide are more than 5,050 salaried physicians and researchers, and 17,800 registered nurses and advanced practice providers, representing 140 medical specialties and subspecialties. Cleveland Clinic is a 6,500-bed health system that includes a 173-acre main campus near downtown Cleveland, 21 hospitals, more than 220 outpatient facilities, including locations in northeast Ohio; southeast Florida; Las Vegas, Nevada; Toronto, Canada; Abu Dhabi, UAE; and London, England. In 2021, there were 10.2 million total outpatient visits, 304,000 hospital admissions and observations, and 259,000 surgical cases throughout Cleveland Clinic’s health system. Patients came for treatment from every state and 185 countries. Visit us at clevelandclinic.org. Follow us at twitter.com/ClevelandClinic. News and resources available at newsroom.clevelandclinic.org.